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Lodgepole Creek is a tributary of the South Platte River, approximately 212 miles (341 km) long, in the U.S. states of Wyoming, Nebraska and Colorado. Lodgepole Creek drains the southeastern corner of Wyoming, the southern edge of the Nebraska Panhandle and a several small portions of northeastern Colorado. As its name implies, Lodgepole Creek is a very small stream; for nearly all of its length, it flows through the semiarid High Plains. The Lodgepole Creek valley has been a major transportation route for over 100 years; the line of the original transcontinental railroad, the Lincoln Highway/U.S. Highway 30 and Interstate 80 all run along the stream for much of its length.